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Ribosomal RNA 2′- O -methylations regulate translation by impacting ribosome dynamics

Abstract : Significance The presence of RNA chemical modifications has long been known, but their precise molecular consequences remain unknown. 2′- O -methylation is an abundant modification that exists in RNA in all domains of life. Ribosomal RNA (rRNA) represents a functionally important RNA that is heavily modified by 2′- O -methylations. Although abundant at functionally important regions of the rRNA, the contribution of 2′- O -methylations to ribosome activities is unknown. By establishing a method to disturb rRNA 2′- O -methylation patterns, we show that rRNA 2′- O -methylations affect the function and fidelity of the ribosome and change the balance between different ribosome conformational states. Our work links 2′- O -methylation to ribosome dynamics and defines a set of critical rRNA 2′- O -methylations required for ribosome biogenesis and others that are dispensable.
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Submitted on : Friday, March 18, 2022 - 9:50:34 AM
Last modification on : Tuesday, May 10, 2022 - 3:18:10 PM

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Sohail Khoshnevis, R. Elizabeth Dreggors-Walker, Virginie Marchand, Yuri Motorin, Homa Ghalei. Ribosomal RNA 2′- O -methylations regulate translation by impacting ribosome dynamics. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2022, 119 (12), pp.e2117334119. ⟨10.1073/pnas.2117334119⟩. ⟨hal-03612834⟩



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