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Journal Articles Viruses Year : 2022

Multiorgan and Vascular Tropism of SARS-CoV-2

Charles Mazeaud


Although the respiratory tract is the main target of SARS-CoV-2, other tissues and organs are permissive to the infection. In this report, we investigated this wide-spectrum tropism by studying the SARS-CoV-2 genetic intra-host variability in multiple tissues. The virological and histological investigation of multiple specimens from a post-mortem COVID-19 patient was performed. SARS-CoV-2 genome was detected in several tissues, including the lower respiratory system, cardio-vascular biopsies, stomach, pancreas, adrenal gland, mediastinal ganglion and testicles. Subgenomic RNA transcripts were also detected, in favor of an active viral replication, especially in testicles. Ultra-deep sequencing allowed us to highlight several SARS-CoV-2 mutations according to tissue distribution. More specifically, mutations of the spike protein, i.e., V341A (18.3%), E654 (44%) and H655R (30.8%), were detected in the inferior vena cava. SARS-CoV-2 variability can contribute to heterogeneous distributions of viral quasispecies, which may affect the COVID-19 pathogeny.
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hal-03765141 , version 1 (04-10-2023)




Cédric Hartard, Ahlam Chaqroun, Nicla Settembre, Guillaume Gauchotte, Benjamin Lefevre, et al.. Multiorgan and Vascular Tropism of SARS-CoV-2. Viruses, 2022, 14 (3), pp.515. ⟨10.3390/v14030515⟩. ⟨hal-03765141⟩
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