Multifunctional PLA/Gelatin Bionanocomposites for Tailored Drug Delivery Systems - Université de Lorraine Access content directly
Journal Articles Pharmaceutics Year : 2022

Multifunctional PLA/Gelatin Bionanocomposites for Tailored Drug Delivery Systems

Alberto Juan
Murillo Donizeti
  • Function : Author
Jesus Valcarcel
José Vazquez
Eduardo Solano
David Chapron
  • Function : Author
Patrice Bourson
Ivan Bravo
Carlos Alonso-Moreno
Pilar Clemente-Casares
  • Function : Author
Carlos Gracia-Fernández
  • Function : Author
Alessandro Longo
  • Function : Author
Georges Salloum-Abou-Jaoude
Alberto Ocaña
Manuel Piñeiro
Carolina Hermida-Merino
Daniel Hermida-Merino
  • Function : Correspondent author
  • PersonId : 1087097

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A series of bionanocomposites composed of shark gelatin hydrogels and PLA nanoparticles featuring different nanostructures were designed to generate multifunctional drug delivery systems with tailored release rates required for personalized treatment approaches. The global conception of the systems was considered from the desired customization of the drug release while featuring the viscoelastic properties needed for their ease of storage and posterior local administration as well as their biocompatibility and cell growth capability for the successful administration at the biomolecular level. The hydrogel matrix offers the support to develop a direct thermal method to convert the typical kinetic trapped nanostructures afforded by the formulation method whilst avoiding the detrimental nanoparticle agglomeration that diminishes their therapeutic effect. The nanoparticles generated were successfully formulated with two different antitumoral compounds (doxorubicin and dasatinib) possessing different structures to prove the loading versatility of the drug delivery system. The bionanocomposites were characterized by several techniques (SEM, DLS, RAMAN, DSC, SAXS/WAXS and rheology) as well as their reversible sol–gel transition upon thermal treatment that occurs during the drug delivery system preparation and the thermal annealing step. In addition, the local applicability of the drug delivery system was assessed by the so-called “syringe test” to validate both the storage capability and its flow properties at simulated physiological conditions. Finally, the drug release profiles of the doxorubicin from both the PLA nanoparticles or the bionanocomposites were analyzed and correlated to the nanostructure of the drug delivery system.
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Dates and versions

hal-03781155 , version 1 (20-09-2022)



Carmen Moya-Lopez, Alberto Juan, Murillo Donizeti, Jesus Valcarcel, José Vazquez, et al.. Multifunctional PLA/Gelatin Bionanocomposites for Tailored Drug Delivery Systems. Pharmaceutics, 2022, 14 (6), pp.1138. ⟨10.3390/pharmaceutics14061138⟩. ⟨hal-03781155⟩
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