The Association of Smoking with Hospitalization and Mortality Differs According to Sex in Patients with Heart Failure Following Myocardial Infarction - Université de Lorraine
Article Dans Une Revue Journal of Women's Health Année : 2022

The Association of Smoking with Hospitalization and Mortality Differs According to Sex in Patients with Heart Failure Following Myocardial Infarction

Trygve Sundby Hall
  • Fonction : Auteur
  • PersonId : 1172689

Résumé

Background: Smoking has been associated with higher morbidity and mortality following myocardial infarction (MI), but reports of the impact on morbidity and mortality for females and elderly patients experiencing MI complicated with left ventricular dysfunction or overt heart failure are limited. Methods: In an individual patient data meta-analysis of high-risk MI patients, the association of smoking with hospitalizations and death were investigated. Weighted Cox proportional hazard modelling were used to study the risks of smoking on adjudicated endpoints among different sex and age categories. Results: 28,735 patients from the CAPRICORN, EPHESUS, OPTIMAAL and VALIANT trials were assessed. After weighting, smokers (N=18,148) were unfrequently women (29.2%) and a minority were above ≥80 years (9.8%). Smoking was significantly more associated with all-cause hospitalizations in women (hazard ratio (HR) 1.24; 95% confidence interval (CI) 1.16-1.32) than in men (HR=1.10; CI 1.05-1.16) resulting in a significant interaction between smoking and sex (p=0.005). Smoking was predictive of all-cause mortality homogenously across age categories (p for interaction=0.25) and sex (p for interaction=0.58). Conclusions: The influence of smoking on morbidity differed according to sex following high-risk MI. The deleterious impact of smoking on hospitalization appeared particularly potent in women, which should further reinforce preventive strategies in females.
Fichier principal
Vignette du fichier
MS -final.pdf (939.65 Ko) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03807855 , version 1 (10-10-2022)

Identifiants

Citer

Trygve Sundby Hall, Stein Ørn, Faiez Zannad, Patrick Rossignol, Kevin Duarte, et al.. The Association of Smoking with Hospitalization and Mortality Differs According to Sex in Patients with Heart Failure Following Myocardial Infarction. Journal of Women's Health, 2022, 31 (3), pp.310-320. ⟨10.1089/jwh.2021.0326⟩. ⟨hal-03807855⟩
30 Consultations
140 Téléchargements

Altmetric

Partager

More