Emerging role of IκBζ in inflammation: Emphasis on psoriasis
Résumé
Expression of NFKBIZ is stimulated by cytokines such as IL-17, TNFα, IL-1β and IL-36. Increased expression of IκBζ eventually activates NF-κB leading to increased expression of various proinflammatory cytokines, chemokines, as well as psoriasis-associated genes. This cascade of molecules causes recruitment of neutrophils and other immune-mediated inflammatory cells, which consequently leads to the development of psoriasis-like skin inflammation.
Domaines
Sciences du Vivant [q-bio]| Origine | Publication financée par une institution |
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