Lipophilicity prediction of three photosensitizers by liquid–liquid extraction, HPLC, and DFT methods - Université de Lorraine Access content directly
Journal Articles Luminescence Year : 2022

Lipophilicity prediction of three photosensitizers by liquid–liquid extraction, HPLC, and DFT methods

Abstract

Photodynamic therapy (PDT) is a method of treating precancerous diseases and malignant neoplasms. The efficacy of PDT depends on different parameters such as light dosimetry, oxygen availability, and photophysical and physical-chemical properties of the photosensitizer. In PDT, a photosensitizer is activated using light to promote oxygen photosensitization and cellular transport plays a key role in the reach of it the desired tissue. In particular, to know the effectiveness of the drug delivery in PDT and its dosage forms to target damaged organs, along with such characteristics as water solubility, it is important to know the ability of a substance to penetrate through cell membrane or accumulate in it. The lipophilicity is used to quantify the above-described abilities. We evaluated the lipophilicity of three selected PS protoporphyrin IX, pyropheophorbide-a and photofrin by means of three different methods: octanol-water distribution methods (Shake-flask), reversed-phase high-performance liquid chromatography (HPLC) and theoretical calculations based on density functional theory (DFT). We describe and compare the results of these various methods.
Fichier principal
Vignette du fichier
Article LogP for luminescence-CF-figures.pdf (1.04 Mo) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-03863319 , version 1 (28-11-2022)

Identifiers

Cite

Bauyrzhan Myrzakhmetov, Jonathan Honorien, Philippe Arnoux, René Fournet, Irina Tsoy, et al.. Lipophilicity prediction of three photosensitizers by liquid–liquid extraction, HPLC, and DFT methods. Luminescence, 2022, 37 (9), pp.1597-1608. ⟨10.1002/bio.4336⟩. ⟨hal-03863319⟩
8 View
49 Download

Altmetric

Share

Gmail Facebook X LinkedIn More