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Journal Articles Biosensors Year : 2020

Interdigitated Sensor Optimization for Blood Sample Analysis

Julien Claudel
Thanh Tuan Ngo
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  • IdRef : 188092870
Djilali Kourtiche
Mustapha Nadi

Abstract

Interdigitated (ITD) sensors are specially adapted for the bioimpedance analysis (BIA) of low-volume (microliter scale) biological samples. Impedance spectroscopy is a fast method involving simple and easy biological sample preparation. The geometry of an ITD sensor makes it easier to deposit a sample at the microscopic scale of the electrodes. At this scale, the electrode size induces an increase in the double-layer effect, which may completely limit interesting bandwidths in the impedance measurements. This work focuses on ITD sensor frequency band optimization via an original study of the impact of the metalization ratio α. An electrical sensor model was studied to determine the best α ratio. A ratio of 0.6 was able to improve the low-frequency cutoff by a factor of up to 2.5. This theoretical approach was confirmed by measurements of blood samples with three sensors. The optimized sensor was able to extract the intrinsic electrical properties of blood in the frequency band of interest.

Dates and versions

hal-03919101 , version 1 (02-01-2023)

Identifiers

Cite

Julien Claudel, Thanh Tuan Ngo, Djilali Kourtiche, Mustapha Nadi. Interdigitated Sensor Optimization for Blood Sample Analysis. Biosensors, 2020, 10 (12), pp.208. ⟨10.3390/bios10120208⟩. ⟨hal-03919101⟩
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