Urinary Marker Profiles in Heart Failure with Reduced Versus Preserved Ejection Fraction - Université de Lorraine Access content directly
Journal Articles Journal of Cardiovascular Translational Research Year : 2023

Urinary Marker Profiles in Heart Failure with Reduced Versus Preserved Ejection Fraction

Chim C Lang
  • Function : Author

Abstract

Background: Recent data suggest different causes of renal dysfunction between heart failure with reduced (HFrEF) versus preserved ejection fraction (HFpEF). We therefore studied a wide range of urinary markers reflecting different nephron segments in heart failure patients. Methods: In 2070, in chronic heart failure patients, we measured several established and upcoming urinary markers reflecting different nephron segments. Results: Mean age was 70 ± 12 years, 74% was male and 81% (n = 1677) had HFrEF. Mean estimated glomerular filtration rate (eGFR) was lower in patients with HFpEF (56 ± 23 versus 63 ± 23 ml/min/1.73 m2, P = 0.001). Patients with HFpEF had significantly higher values of NGAL (58.1 [24.0-124.8] versus 28.1 [14.6-66.9] μg/gCr, P < 0.001) and KIM-1 (2.28 [1.49-4.37] versus 1.79 [0.85-3.49] μg/gCr, P = 0.001). These differences were more pronounced in patients with an eGFR > 60 ml/min/1.73m2. Conclusions: HFpEF patients showed more evidence of tubular damage and/or dysfunction compared with HFrEF patients, in particular when glomerular function was preserved.
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Licence : CC BY - Attribution
Licence : CC BY - Attribution

Dates and versions

hal-04011124 , version 1 (02-03-2023)

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Koen W Streng, Hans L Hillege, Jozine M ter Maaten, Dirk J van Veldhuisen, Kenneth Dickstein, et al.. Urinary Marker Profiles in Heart Failure with Reduced Versus Preserved Ejection Fraction. Journal of Cardiovascular Translational Research, 2023, ⟨10.1007/s12265-023-10356-y⟩. ⟨hal-04011124⟩
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