Risankizumab as induction therapy for Crohn's disease: results from the phase 3 ADVANCE and MOTIVATE induction trials
Geert d'Haens
(1)
,
Remo Panaccione
(2)
,
Filip Baert
(3)
,
Peter Bossuyt
(4)
,
Jean-Frederic Colombel
(5)
,
Silvio Danese
(6, 7)
,
Marla Dubinsky
(5)
,
Brian Feagan
(8)
,
Tadakazu Hisamatsu
(9)
,
Allen Lim
(10)
,
James Lindsay
(11)
,
Edward Loftus
(12)
,
Julian Panés
(13, 14, 15)
,
Laurent Peyrin-Biroulet
(16, 17)
,
Zhihua Ran
(18, 19, 20)
,
David Rubin
(21)
,
William Sandborn
(22)
,
Stefan Schreiber
(23, 24)
,
Ezequiel Neimark
(25)
,
Alexandra Song
(25)
,
Kristina Kligys
(25)
,
Yinuo Pang
(25)
,
Valerie Pivorunas
(25)
,
Sofie Berg
(25)
,
W Rachel Duan
(25)
,
Bidan Huang
(25)
,
Jasmina Kalabic
(26)
,
Xiaomei Liao
(25)
,
Anne Robinson
(25)
,
Kori Wallace
(25)
,
Marc Ferrante
(27)
1
Amsterdam UMC -
Amsterdam University Medical Centers
2 University of Calgary
3 AZ Delta
4 Imelda General Hospital
5 Mount Sinai School of Medicine
6 UniSR - Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie]
7 IRCCS San Raffaele Hospital
8 UWO - University of Western Ontario
9 Kyorin University School of Medicine [Tokyo, Japan]
10 University of Alberta
11 Bart's and The London School of Medicine and Dentistry
12 Mayo Clinic College of Medicine
13 IDIBAPS - Institut d'Investigacions Biomèdiques August Pi i Sunyer
14 CIBERehd - Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas y Digestivas
15 Clinic Barcelona Hospital Universitari
16 Service d'Hépato-gastro-entérologie [CHRU Nancy]
17 NGERE - Nutrition-Génétique et Exposition aux Risques Environnementaux
18 Inflammatory Bowel Disease Research Center [Shanghai]
19 Shanghai Jiao Tong University [Shanghai]
20 Institute of Digestive Disease, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
21 The University of Chicago Medicine [Chicago]
22 UC San Diego - University of California [San Diego]
23 UKSH - University Medical Center of Schleswig–Holstein = Universitätsklinikum Schleswig-Holstein
24 CAU - Christian-Albrechts-Universität zu Kiel = Christian-Albrechts University of Kiel = Université Christian-Albrechts de Kiel
25 Abbvie Inc. [North Chicago]
26 AbbVie Deutschland GmbH & Co KG
27 KU Leuven - Catholic University of Leuven = Katholieke Universiteit Leuven
2 University of Calgary
3 AZ Delta
4 Imelda General Hospital
5 Mount Sinai School of Medicine
6 UniSR - Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie]
7 IRCCS San Raffaele Hospital
8 UWO - University of Western Ontario
9 Kyorin University School of Medicine [Tokyo, Japan]
10 University of Alberta
11 Bart's and The London School of Medicine and Dentistry
12 Mayo Clinic College of Medicine
13 IDIBAPS - Institut d'Investigacions Biomèdiques August Pi i Sunyer
14 CIBERehd - Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas y Digestivas
15 Clinic Barcelona Hospital Universitari
16 Service d'Hépato-gastro-entérologie [CHRU Nancy]
17 NGERE - Nutrition-Génétique et Exposition aux Risques Environnementaux
18 Inflammatory Bowel Disease Research Center [Shanghai]
19 Shanghai Jiao Tong University [Shanghai]
20 Institute of Digestive Disease, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
21 The University of Chicago Medicine [Chicago]
22 UC San Diego - University of California [San Diego]
23 UKSH - University Medical Center of Schleswig–Holstein = Universitätsklinikum Schleswig-Holstein
24 CAU - Christian-Albrechts-Universität zu Kiel = Christian-Albrechts University of Kiel = Université Christian-Albrechts de Kiel
25 Abbvie Inc. [North Chicago]
26 AbbVie Deutschland GmbH & Co KG
27 KU Leuven - Catholic University of Leuven = Katholieke Universiteit Leuven
Résumé
Risankizumab, an interleukin (IL)-23 p19 inhibitor, was evaluated for safety and efficacy as induction therapy in patients with moderately to severely active Crohn's disease.
AbbVie.