Reactive oxygen species production by photoexcited (CuInS2)x(ZnS)1-x quantum dots and their phototoxicity towards Staphylococcus aureus bacteria - Université de Lorraine Access content directly
Journal Articles Journal of Photochemistry and Photobiology A: Chemistry Year : 2024

Reactive oxygen species production by photoexcited (CuInS2)x(ZnS)1-x quantum dots and their phototoxicity towards Staphylococcus aureus bacteria

Abstract

The photoproduction of reactive oxygen species (ROS) by semiconductor nanocrystals is of high interest for biological and environmental applications. Herein, water-dispersible 3-mercaptopropionic (MPA)-capped (CuInS2)x(ZnS)1-x quantum dots (ZCIS@MPA QDs) were prepared from dodecanethiol-capped ZCIS QDs by a ligand exchange and their photoreactivity was evaluated. By combining colorimetric and fluorescent probes with electron spin resonance (ESR) measurements, we showed that ZCIS@MPA QDs can photogenerate ROS like hydroxyl ●OH and superoxide O2●- radicals and singlet oxygen 1O2 that alter the MPA ligand and participate in photoluminescence quenching. The phototoxicity of ZCIS@MPA QDs against S. aureus bacteria and the inhibition of the cell growth on a surface were further investigated. These deleterious effects of ROS photoproduced by ZCIS@MPA QDs could significantly be reduced by coupling the antioxidant glutathione peptide with the QDs. Our findings enrich the understanding of photochemical reactions mediated by ZCIS@MPA QDs but also provide new pathways for ROS production, even under ambient light, that may be valuable for antibacterial applications like surface disinfection.
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Dates and versions

hal-04209295 , version 1 (16-09-2023)

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Wojciech Białowąs, Rym Boudjemaa, Karine Steenkeste, Pauline Nyssen, Maryse Hoebeke, et al.. Reactive oxygen species production by photoexcited (CuInS2)x(ZnS)1-x quantum dots and their phototoxicity towards Staphylococcus aureus bacteria. Journal of Photochemistry and Photobiology A: Chemistry, 2024, 446, pp.115165. ⟨10.1016/j.jphotochem.2023.115165⟩. ⟨hal-04209295⟩
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