Histologic Features of Colon Biopsies (Geboes Score) Associated With Progression of Ulcerative Colitis for the First 36 Months After Biopsy
Fernando Magro
(1, 2)
,
Catarina Alves
(2)
,
Joanne Lopes
(1)
,
Susana Lopes
(1)
,
Helena Tavares de Sousa
(3)
,
José Cotter
(4, 5)
,
Vitor Macedo da Silva
(4)
,
Paula Lago
(6)
,
Ana Vieira
(7)
,
Mariana Brito
(7)
,
Maria A.M. Duarte
(8)
,
Francisco Portela
(9)
,
João Silva
(10)
,
Paula Ministro
(11)
,
Bruno Arroja
(12)
,
Liliana Carvalho
(13)
,
Joana Torres
(14)
,
Mafalda Santiago
(15)
,
Maria Manuela Estevinho
(2)
,
Silvio Danese
(16, 17)
,
Laurent Peyrin-Biroulet
(18, 19)
,
Cláudia Camila Dias
(15, 2)
,
Paula Borralho
(20)
,
Roger Feakins
(21)
,
Fátima Carneiro
(22)
1
Hospital de São João [Porto]
2 FMUP - Faculdade de Medicina da Universidade do Porto
3 UAlg - Universidade do Algarve
4 Hospital da Senhora da Oliveira [Guimarães]
5 Universidade do Minho = University of Minho [Braga]
6 Centro Hospitalar do Porto
7 EPE - Hospital Garcia de Orta
8 Hospital do Divino Espirito Santo
9 H.U.C. - Hospitais da Universidade de Coimbra
10 Instituto Português de Oncologia de Lisboa
11 CHTV - Centro Hospitalar Tondela-Viseu [Viseu, Portugal]
12 Hospital Escala Braga [Braga, Portugal]
13 Centro Hospitalar de Lisboa Ocidental [Lisbonne]
14 Hospital Beatriz Ângelo
15 CINTESIS - Center of Research in Health Technologies and Information Systems
16 Hunimed - Humanitas University [Milan]
17 Humanitas Clinical and Research Center [Rozzano, Milan, Italy]
18 Service d'Hépato-gastro-entérologie [CHRU Nancy]
19 NGERE - Nutrition-Génétique et Exposition aux Risques Environnementaux
20 Faculdade de Medicina [Lisboa]
21 Royal Free Hospital [London, UK]
22 Universidade do Porto = University of Porto
2 FMUP - Faculdade de Medicina da Universidade do Porto
3 UAlg - Universidade do Algarve
4 Hospital da Senhora da Oliveira [Guimarães]
5 Universidade do Minho = University of Minho [Braga]
6 Centro Hospitalar do Porto
7 EPE - Hospital Garcia de Orta
8 Hospital do Divino Espirito Santo
9 H.U.C. - Hospitais da Universidade de Coimbra
10 Instituto Português de Oncologia de Lisboa
11 CHTV - Centro Hospitalar Tondela-Viseu [Viseu, Portugal]
12 Hospital Escala Braga [Braga, Portugal]
13 Centro Hospitalar de Lisboa Ocidental [Lisbonne]
14 Hospital Beatriz Ângelo
15 CINTESIS - Center of Research in Health Technologies and Information Systems
16 Hunimed - Humanitas University [Milan]
17 Humanitas Clinical and Research Center [Rozzano, Milan, Italy]
18 Service d'Hépato-gastro-entérologie [CHRU Nancy]
19 NGERE - Nutrition-Génétique et Exposition aux Risques Environnementaux
20 Faculdade de Medicina [Lisboa]
21 Royal Free Hospital [London, UK]
22 Universidade do Porto = University of Porto
Abstract
In addition to findings from endoscopy, histologic features of colon biopsies have been associated with outcomes of patients with ulcerative colitis (UC). We investigated associations between Geboes scores (a system to quantify structural changes and inflammatory activity in colon biopsies) and UC progression, and the time period over which this association is valid.