Exploring the Mechanical and Chemical Properties of Cross-Linked Poly(allylamine)-hyaluronic Acid Multilayer Films Using a Chemometric Unmixing Approach - Université de Lorraine Accéder directement au contenu
Article Dans Une Revue ACS Applied Polymer Materials Année : 2023

Exploring the Mechanical and Chemical Properties of Cross-Linked Poly(allylamine)-hyaluronic Acid Multilayer Films Using a Chemometric Unmixing Approach

Résumé

For several decades now, modulating and controlling the mechanical properties of hydrogels, and in particular exponentially growing polyelectrolyte multilayer films (PEM), have been a major challenge, given their importance for a wide range of applications including tissue engineering, implantable biomaterials and drug delivery systems. In this work, we compared the crosslinking reaction of hydrogels based on the association of poly(allylamine) (PAH) and hyaluronic acid (HA) with either 1,4-butanediol diglycidyl ether (BDDE) or divinylsulfone (DVS) at different concentrations. On the basis of infrared data analysis by means of a chemometric method, we demonstrated that the cross-linking reaction led to significant changes in their chemical features. We deciphered how the affinity of each cross linker to alcohol and amino chemical functions drives the chemical features of the PEMs. These features can be described by a linear combination of pure HA-BDDE, PAH-BDDE or HA-DVS, PAH-DVS based hydrogels with ratios of 80% and 16% for the BDDE, and 55% and 45% for the DVS reactions, respectively. Furthermore, the mechanical properties resulting from the BDDE crosslinking reaction were consistent with a high mechanical contribution of HA-BDDE as estimated by the chemometric analysis. However, this linear combination cannot be applied for DVS. Indeed, the crosslinked PEM was softer than expected regarding the chemical contributions of HA-DVS and PAH-DVS. Our results show that it is possible to control the mechanical and chemical features by the choice of the crosslinkers alone or in a mixture.

Domaines

Chimie
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hal-04269188 , version 1 (03-11-2023)

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Copyright (Tous droits réservés)

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Saeid Ekrami, Fabienne Quilès, Alice Schollhammer, Xavier Bellanger, Erwan André, et al.. Exploring the Mechanical and Chemical Properties of Cross-Linked Poly(allylamine)-hyaluronic Acid Multilayer Films Using a Chemometric Unmixing Approach. ACS Applied Polymer Materials, 2023, 5 (10), pp.8533-8546. ⟨10.1021/acsapm.3c01663⟩. ⟨hal-04269188⟩
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