Trisomy 21 (T21), also called Down’s syndrome constitutes the most frequent chromosomal anomaly in the world. Screening today is fixed in pregnancy monitoring as systematically proposed to pregnant women. Regardless of what the results may be from the T21 screening the professional has a responsibility of delivering information in a respectful manner, as this may affect the patients and couples experience during the procedure and there after. Method: It is about a qualitative observational study directed by interviews semistructured, the patients who have been tested on the combined screening of T21. It has been conducted between November 2019 and January 2020 within the maternity wards of the regional hospital Metz-Thionville on the women who gave birth to a child who don’t have trisomy 21 or other pathology. Results: The study showed that the patient’s decision to undergo the screening can be influenced by others. It was noted that this test was not clearly defined, therefore patients were unaware that this test is optional unlike other regular pregnancy monitoring tests. The patient’s knowledge of the overall subject and testing was quite poor, however the information provided to them was often ambiguous and lacking clarity. The quality of service greatly impacts the decision made by the patient to undergo testing; this can be positive or negative depending on the service received. The women reported feeling stressed during the waiting period, and were relieved when the results were delivered to them. Conclusion: This study shows the relationship between delivered information and the screening experience: some of the patients reported feeling reassured, however some reported feeling anxious. It also shows that the practices undertaken by the professionals who delivered the information could be improved through providing the patients with quality resources and information, along with improved communication