Sepsis-associated acute kidney injury: recent advances in enrichment strategies, sub-phenotyping and clinical trials - Université de Lorraine Accéder directement au contenu
Article Dans Une Revue Critical Care Année : 2024

Sepsis-associated acute kidney injury: recent advances in enrichment strategies, sub-phenotyping and clinical trials

Matthieu Legrand
  • Fonction : Auteur
  • PersonId : 1082453
Jay Koyner
  • Fonction : Auteur
Kevin Chung
  • Fonction : Auteur
Juliane Bernholz
  • Fonction : Auteur

Résumé

Abstract Acute kidney injury (AKI) often complicates sepsis and is associated with high morbidity and mortality. In recent years, several important clinical trials have improved our understanding of sepsis-associated AKI (SA-AKI) and impacted clinical care. Advances in sub-phenotyping of sepsis and AKI and clinical trial design offer unprecedented opportunities to fill gaps in knowledge and generate better evidence for improving the outcome of critically ill patients with SA-AKI. In this manuscript, we review the recent literature of clinical trials in sepsis with focus on studies that explore SA-AKI as a primary or secondary outcome. We discuss lessons learned and potential opportunities to improve the design of clinical trials and generate actionable evidence in future research. We specifically discuss the role of enrichment strategies to target populations that are most likely to derive benefit and the importance of patient-centered clinical trial endpoints and appropriate trial designs with the aim to provide guidance in designing future trials.
Fichier principal
Vignette du fichier
s13054-024-04877-4.pdf (1.67 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Licence : CC BY - Paternité

Dates et versions

hal-04517641 , version 1 (22-03-2024)

Licence

Paternité

Identifiants

Citer

Matthieu Legrand, Sean M Bagshaw, Pavan K Bhatraju, Azra Bihorac, Ellen Caniglia, et al.. Sepsis-associated acute kidney injury: recent advances in enrichment strategies, sub-phenotyping and clinical trials. Critical Care, 2024, 28 (1), pp.92. ⟨10.1186/s13054-024-04877-4⟩. ⟨hal-04517641⟩

Collections

UNIV-LORRAINE
1 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More