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Le contenu de l'angle ponto-cérébelleux : artères et mouvements : morphogenèse, anatomie statique et dynamique

Abstract : Several vascular and nervous structures are located within the cerebello-pontine angle. In certain pathological conditions, microvascular compression syndroms may occur, where an artery or a vein is compressing a cranial nerve. The purpose of this work in three parts is to investigate some anatomical and physiological bases of these microvascular compression syndroms. The first part focuses on the vertebrobasilar system morphogenesis. A special designed 3D reconstruction original software allowed us to reformate four human embryos from histological serial sections. The three-dimensional views are confirming the classical features thus creating the basis of a larger study based on multiple embryos. The second part shows for the first time the physiological motion of the vestibulo-cochlear nerve at the level of the cerebello-pontine angle, with the help of a phase-contrast MRI sequence. The cranio-caudal and antero-posterior directions and their amplitudes have been studied. These motions are cardiac-cycle-dependant. We used an "oscillating string" model to explain the VCN motion between the brain stem and the fundus of the internal acoustic meatus. The third part of this work is focused on a preliminary study of the variability of the vertebro-basilar arterial fusion along the lifetime. An original software has been designed and allowing the normalisation from nine post-contrast cerebral CT scanners. A ?mean? brain stem was obtained and visualized in front of nine arterial fusion points.
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  • HAL Id : tel-01746229, version 1


Marc Labrousse. Le contenu de l'angle ponto-cérébelleux : artères et mouvements : morphogenèse, anatomie statique et dynamique. Médecine humaine et pathologie. Université Henri Poincaré - Nancy 1, 2011. Français. ⟨NNT : 2011NAN10078⟩. ⟨tel-01746229⟩



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