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Etude des relations structure-activité en allergie médicamenteuse

Abstract : Structure-Activity Relationships (SAR) refer to the relation between chemical structure and pharmacological activity for a series of compounds (IUPAC, 1998). They have been used in the pharmaceutical, chemical and cosmetic industries, especially for drug and chemical design purposes. After reviewing literature data, we describe SAR-based approaches based on skin and laboratory tests in immediate drug hypersensitivity (beta-lactam antibiotics, MRI contrast agents, neuromuscular blocking agents, insulin) as well as in delayed drug hypersensitivity (iodixanol, iodinated contrast media). Our findings demonstrate a link between chemical structure and allergenic potential of a molecule. Structure-activity relationships can prove useful to: (i) identify allergenic determinants on the basis of cross-reactivity studies, (ii) predict the likelihood of hypersensitivity reactions to related molecules and select safe alternatives on a non-empirical basis
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Submitted on : Thursday, March 29, 2018 - 10:29:13 AM
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  • HAL Id : tel-01746257, version 1



Frédéric Hasdenteufel. Etude des relations structure-activité en allergie médicamenteuse. Médecine humaine et pathologie. Université Henri Poincaré - Nancy 1, 2011. Français. ⟨NNT : 2011NAN10114⟩. ⟨tel-01746257⟩



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