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Facteurs environnementaux et génétiques pouvant influencer l'apparition de la rigidité artérielle : étude du rat Zucker et de la souris Klotho

Abstract : The cardiovascular consequences of aging are a leading cause of death. In addition to chronological age, several other factors may influence the onset of changes associated with aging. The study of genetic and environmental determinants of cardiovascular aging accelerators could improve prevention of these diseases. We have demonstrated in very old (80 weeks) Zucker rats (model of metabolic syndrome) that obesity and associated metabolic disorders act synergistically with aging to alter the vascular structure and function by targeting endothelial properties. The early increase in plasma free fatty acids (FFA) and alterations in carotid responsiveness induced by AGL are key mechanisms of development of arterial stiffness in this model. Mouse deficient for the gene Klotho (Kl) has a short life expectancy, accelerated aging and diseases similar to an old man. We characterized the arterial phenotype (unknown) mice Kl +/- at 6 and 12 months, compared to their controls K +/+ at the same ages. We have demonstrated in this model that in basal conditions, Kl +/- mice show no phenotype of an accelerated aging of the arterial wall at the age of 12 months. However, at the age of 6 months, mice Kl +/- show an increase in carotid stiffness in favor of an alteration of vascular function. The study of these two models has allowed us to assess the implication of obesity and Klotho protein in aging arteries
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Natacha Sloboda. Facteurs environnementaux et génétiques pouvant influencer l'apparition de la rigidité artérielle : étude du rat Zucker et de la souris Klotho. Médecine humaine et pathologie. Université Henri Poincaré - Nancy 1, 2011. Français. ⟨NNT : 2011NAN10108⟩. ⟨tel-01746259⟩

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