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Explorations des fonctions plaquettaires exposées à l'aspirine au décours de l'accident vasculaire cérébral ischémique

Abstract : Aspirin is the most commonly used antiplatelet treatment during the acute phase of cerebral ischemic events. But, despite this protection, early ischemic recurrences are frequent, and considered as clinical failures of this therapy. We studied laboratory parameters of the first 300 mg oral dose of aspirin given, within 48 hours, after ischemic cerebral event. Fifty patients were included. For all patients, two blood sampling were performed, the first, during the third hour after aspirin intake (T1) and the second during the twenty-fourth hour (T2). For patients already treated with a daily dose of aspirin, a supplementary withdrawn was done before aspirin intake (T0). Platelet reactivity was studied on the basis of serum thromboxane (TX) B2 levels and light transmission aggregometry after stimulation of platelet-rich plasma by acid arachidonic and collagen 2µg/mL reported to results with collagen 20 µg/mL (ratio Col2/20). Inhibition of platelet activity was observed, at T1, for all patients. There is a significant increase of TXB2 values, and of relative values of the ratio Col2/20, at T2 as compared to T1. For already aspirin treated patients, there is a significant decrease of TXB2 levels at T1 as compared to T0. There is a platelet reactivity recovery within 24 hours, following the first 300 mg oral dose of aspirin, during the acute phase of a cerebral ischemic event, and demonstrated by TXB2 levels and ratio Col2/20. This fact would favour early ischemic recurrences. However, this dose is able to complete the inhibition of the TXA2 pathway for already aspirin treated patients
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Theses
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http://docnum.univ-lorraine.fr/prive/SCD_T_2011_0132_RICHARD.pdf
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https://hal.univ-lorraine.fr/tel-01746289
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Submitted on : Thursday, March 29, 2018 - 10:30:12 AM
Last modification on : Thursday, March 5, 2020 - 11:26:30 AM

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  • HAL Id : tel-01746289, version 1

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Sébastien Richard. Explorations des fonctions plaquettaires exposées à l'aspirine au décours de l'accident vasculaire cérébral ischémique. Médecine humaine et pathologie. Université Henri Poincaré - Nancy 1, 2011. Français. ⟨NNT : 2011NAN10132⟩. ⟨tel-01746289⟩

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