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Phytochemical and Biological Study of Sudanese Plants: Hydnora johannis Becc. (Hydnoraceae) and Citrullus lanatus (Thunb.) Matsum. et Nakai var. citroides (Bailey) Mansf. (Cucurbitaceae)

Abstract : Different extracts were prepared from the roots of H. johannis and different biological tests were performed. Water extract exhibited significant activity against Enterococcus fecalis, Staphylococcus aureus and Bacillus. Water extract devoid from tannin or the tannin fraction did not show any antibacterial activity reflecting the synergistic property of active compounds. Both extracts showed antifungal, antiradical capacity as well as antiglycation activity. Toxicological study of the powder and ethanol extract on rats showed toxicity to the liver and kidney tissues. Five compounds were isolated namely; 3,4,5- Trihydroxy- 6,7-dimethoxy flavone ; 3,5-Dihydroxy- 4,7- dimethoxy dihydroflavonol, Catechin, Vanillin and Protocatechuic acid. Stigmasterol, Oleic acid, Myristic acid and Palmitic acid were also identified. A study on the fruit pulps of C. lanatus var. citroides revealed that the methanolic extract displayed an antibacterial activity against B. subtilis, S. aureus and E. coli. The butanolic extract showed antiradical capacity and was not toxic to brine shrimps larvae. Two compounds were isolated namely; Cucurbitacine E 2-O-[bêta]-glucopyranoside and Cucurbitacine L 2-O- [bêta] -glucopyranoside. Both compounds showed antibacterial activity against E.coli whereas, Cucurbitacine L 2-O-[bêta]-glucopyranoside showed antibacterial activity against P. aeruginosa as well as antiradical activity
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http://docnum.univ-lorraine.fr/prive/SCD_T_2011_0138_YAGI.pdf
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https://hal.univ-lorraine.fr/tel-01746295
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Submitted on : Thursday, March 29, 2018 - 10:30:19 AM
Last modification on : Thursday, March 5, 2020 - 12:31:08 PM

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Sakina Yagi. Phytochemical and Biological Study of Sudanese Plants: Hydnora johannis Becc. (Hydnoraceae) and Citrullus lanatus (Thunb.) Matsum. et Nakai var. citroides (Bailey) Mansf. (Cucurbitaceae). Human health and pathology. Université Henri Poincaré - Nancy 1, 2011. English. ⟨NNT : 2011NAN10138⟩. ⟨tel-01746295⟩

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