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Élaboration de nouveaux radiotraceurs pour le diagnostic de la Maladie d'Alzheimer

Abstract : The synthesis of new radiotracers to diagnose earlier Alzheimer's disease by Positron Emission Tomography (PET) is a rapidly growing field. Inisitol derivatives, which show aggregative properties to amyloid plaques, have been chosen as scaffold to create and synthesize new radiolabelled compounds for a early diagnostic. Four types of radiotracers have been designed. The first one is the scyllo-inositol in which one hydroxyl group is replaced by a fluorine-18. The second and third generations are inositols in myo and scyllo configurations where the fluorine-18 atom is carried by an alkyl chain. The structure of inositols is then preserved. Finally for the last generation, the alkyl chain bearing the fluorine-18 is introduced via an ether linkage. The synthesis of this type of molecules allows the incorporation of a longer spacer.
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Submitted on : Thursday, March 29, 2018 - 10:31:02 AM
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  • HAL Id : tel-01746318, version 1



Charlotte Collet. Élaboration de nouveaux radiotraceurs pour le diagnostic de la Maladie d'Alzheimer. Autre. Université Henri Poincaré - Nancy 1, 2011. Français. ⟨NNT : 2011NAN10150⟩. ⟨tel-01746318⟩



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