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Influence des composés matriciels sur le signal IRM du cartilage

Abstract : Osteoarthritis (OA) is a common disease observed in elderly population and characterized by a progressive destruction of cartilaginous' tissue. The clinical diagnosis of this disease is realized by, converitional radiography. This method permits to visualize bone modifications related to OA disease (cysts, thickening of the subchondral bone, and osteophyts) but is unable to assess cartilage structure. Due to its high spatial resolution and high contrast between tissues, Magnetic Resonançe Imaging (MRI) is able to visualize the cartilage structure and to differentiate it from adjacent structures (bone, synovial tissue, menisci, and synovial fluid). On a 1,5T cliniciil scan, Fast Spin Echo (FSE) T2-weighted sequences, are able to show variation of internal structure (laminar appearance) of nonnal cartilage and to evaluate morphological alterations of this tissue. During maturation and aging processes, the varîations of signal intensity seem related to the modifications of matrix content and/or collagen network organization in bovine cartilage. Structural modifications of rat patellar cartilage (variation of matrix content, collagen network organization) during maturation and aging processes are studied on a 8.5T experimental imager with the T2 map technique. This quantitative tool shows a decrease of global T2 values and zonal variation of the T2 values, between the superficial and the deep zones in rat cartilage respectively. The T2 map is equally able to depict a slight or severe depletion in proteoglycans characterized by an increase of T2 values as well as in the"superficial than in the deep layers. Finally, this tool offers the opportunity to quantitatively follow the action of anti-inflammatory drugs (steroidal or no steroidal) on the cartilaginous tissue in experimental animal models.
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Submitted on : Thursday, March 29, 2018 - 10:38:16 AM
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Astrid Watrin-Pinzano. Influence des composés matriciels sur le signal IRM du cartilage. Sciences pharmaceutiques. Université Henri Poincaré - Nancy 1, 2001. Français. ⟨NNT : 2001NAN11318⟩. ⟨tel-01746460⟩



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