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Les systèmes neuronaux centraux à galanine : leur rôle dans la neuromodulation des choix alimentaires du rat

Abstract : Galanin (GAL) is an orexigenic neuropeptide, which ability to preferentially stimulate fat intake is discussed. It is cosynthetized in the supraoptic (SON) and paraventricular (PVN) hypothalamic nuclei with another peptide, vasopressin (VP). The mutant Brattleboro rat (DI), is deficient is VP central synthesis and suffers from diabetes insipidus. Its hypothalamo-neurohypophyseal system is hyperstimulated. We observed that GAL and GALmRNA were overexpressed in the SON and PVN of DI rats. DI rats ate 45% fat per day. Both phenomena were found to be independent of the activity of the hypothalamo-neurohypophyseal system and of the phenotypic expression of diabetes insipidus. Central injections of GAL antagonists decreased fat intake in DI rats, proving the involvement of hypothalamic GAL in fat preference. By the use of VP antisense oligonucleotide in normal rats and by immunolesion of VP neurons in heterozygous DI rats, we did not find influence of VP on GAL expression and food intake. Because appearing early in postnatal deyelopment, fat preference and GAL overexpression in DI rats seemed genetically determined.
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http://docnum.univ-lorraine.fr/prive/SCD_T_2000_0088_ODORIZZI.pdf
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Submitted on : Thursday, March 29, 2018 - 10:38:20 AM
Last modification on : Thursday, December 17, 2020 - 11:10:28 AM

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Myriam Odorizzi. Les systèmes neuronaux centraux à galanine : leur rôle dans la neuromodulation des choix alimentaires du rat. Neurosciences [q-bio.NC]. Université Henri Poincaré - Nancy 1, 2000. Français. ⟨NNT : 2000NAN10088⟩. ⟨tel-01746464⟩

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