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Mimes saccharides d'Inositol Phosphate Glycanne : synthèse et propriétés insulo-mimétiques

Abstract : That work deals with the synthesis of O- and C-disaccharide analogues of PIG (Phosphate Inositol Glycan) in order to have a better understanding of its role in the signalisation of insulin. Firstly, th synthesis of eight O-disaccharides, in which the aglycon part (lyxose, arabinose and ribose) includes a cyclic phosphate. Secondly, we present th total synthesis in thirteen steps of C-disaccharide which also includes a cyclic phosphate. The biological activity of those compounds on the cellular growth was measured on human colon adenocarcinomae cells and on dermic fibroblasts. The insulino-mimetic effects of those compounds were evaluated on the glucose uptake in adipocytes.
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Submitted on : Thursday, March 29, 2018 - 10:39:41 AM
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  • HAL Id : tel-01746525, version 1



Olivier Hernout. Mimes saccharides d'Inositol Phosphate Glycanne : synthèse et propriétés insulo-mimétiques. Chimie. Université Henri Poincaré - Nancy 1, 2005. Français. ⟨NNT : 2005NAN10014⟩. ⟨tel-01746525⟩



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