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Nouveaux systèmes complexants et application à la préparation de composés amphiphiles dérivés : Synthèse et étude physicochimique

Abstract : Although there are in infinitesimal quantities in the organism, transition metals have an essential physiological function. They are generally complexed by biological ligands of high molar mass whose study is particularly difficult. It is however possible to model the active sites of these macromolecules using small molecules easier to study. We synthesised histamine-containing pseudo-peptides to simulate the sites of coordination of proteins such as the serum albumin. These peptidoamines are also interesting because of their antioxydant activity. The study of the chelating properties of these molecules with Cu(II) and Ni(II) showed a variety of complexes sometimes very different by their nature and their stability. From these results, we propose new surfactants, with complexing properties, synthesized by connecting a hydrophobic tail to histidine-containing peptides. Polar head corresponds to the pseudo-peptides b-alanyl-histidine and glycyl-glycyl-histidine. Critical micellar concentrations were determined by tensiometry and fluorescence spectroscopy and the binary phase diagrams were plotted. Complexation properties were demonstrated and the species distribution diagrams were determined on model molecules with short hydrophobic chains. Finally, trimodular compounds have been prepared by grafting polyoxyethylene moiety in different parts of the previous molecules to increase hydrophily.
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Theses
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http://docnum.univ-lorraine.fr/prive/SCD_T_2006_0013_GIZZI.pdf
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https://hal.univ-lorraine.fr/tel-01746635
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Submitted on : Thursday, March 29, 2018 - 10:41:39 AM
Last modification on : Friday, February 26, 2021 - 3:24:03 PM

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Patrick Gizzi. Nouveaux systèmes complexants et application à la préparation de composés amphiphiles dérivés : Synthèse et étude physicochimique. Biologie moléculaire. Université Henri Poincaré - Nancy 1, 2006. Français. ⟨NNT : 2006NAN10013⟩. ⟨tel-01746635⟩

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