Skip to Main content Skip to Navigation
Theses

Peptides, hormones et régulation pondérale : impact des conditions nutritionnelles précoces chez le rat

Abstract : We studied the consequences of nutritional manipulations during gestation on hormones and peptides offsprings status. From half gestation, female rats were fed on an adequate well-balanced diet for two third of their energy needs. They were offered the possibility to complete their energy intake through the ingestion of a diet either rich in carbohydrate (HC group) or in fats (HF) or the well-balanced diet (Cr). A other group (C) was fed ad libitum on the balanced diet. At birth, HC and Cr pups were lighter than C and HF pups. At adult age, Cr rats remained lighter while HC tended to be heavier. HF animals did not have any weight problem. At weaning, NPY and AgRP mRNA expression in the arcuate nucleus was significantly higher in the HC pups. In these rats at adulthood, glucose, insulin and leptin plasma levels were increased. Despite this, NPY and AgRP hypothalamic system was not down-regulated while POMC neurons were. We concluded that a central leptin and insulin resistance could exist in these overweight HC rats.
Document type :
Theses
File URL :
http://docnum.univ-lorraine.fr/prive/SCD_T_2004_0233_RICHY.pdf
Complete list of metadatas

https://hal.univ-lorraine.fr/tel-01746701
Contributor : Thèses Ul <>
Submitted on : Thursday, March 29, 2018 - 10:42:56 AM
Last modification on : Tuesday, September 1, 2020 - 3:07:55 PM

Identifiers

  • HAL Id : tel-01746701, version 1

Collections

Citation

Sébastien Richy. Peptides, hormones et régulation pondérale : impact des conditions nutritionnelles précoces chez le rat. Neurosciences [q-bio.NC]. Université Henri Poincaré - Nancy 1, 2004. Français. ⟨NNT : 2004NAN10233⟩. ⟨tel-01746701⟩

Share

Metrics

Record views

9