Skip to Main content Skip to Navigation
Theses

Sensibilité auditive au bruit ou au styrène en fonction de l'âge : expérimentation animale

Abstract : Noise and styrene are two occupational agents that can disrupt the auditory function of exposed subjects. The main goal of this thesis was to evaluate the influence of aging on the auditory sensitivity to noise or styrene in the Long-Evans rat. For this purpose, noise- and styrene-induced hearing losses were studied with 3, 5 and 24 month-old rats. Hearing was tested by recording auditory evoked potentials (EAP) and cubic distortion products (DPOAE). Cochlear hair cell loss and glutamate decarboxylase (GAD) concentrations in inferior colliculus (IC) were also measured.The results showed that aged rats were more sensitive to high-level noise than young rats, but almost insensitive to styrene. In fact, young rats exhibit a hypersensitive period extended beyond the age of 3 months. Finally, GAD concentrations in the IC decreased after a high-level noise but only in the young rats. The central plasticity seems therefore to depend both on age and the nature of the exposure.
Document type :
Theses
File URL :
http://docnum.univ-lorraine.fr/prive/SCD_T_2003_0015_POUYATOS.pdf
Complete list of metadatas

https://hal.univ-lorraine.fr/tel-01746785
Contributor : Thèses Ul <>
Submitted on : Thursday, March 29, 2018 - 10:44:48 AM
Last modification on : Wednesday, October 14, 2020 - 3:57:29 AM

Identifiers

  • HAL Id : tel-01746785, version 1

Collections

Citation

Benoît Pouyatos. Sensibilité auditive au bruit ou au styrène en fonction de l'âge : expérimentation animale. Neurosciences [q-bio.NC]. Université Henri Poincaré - Nancy 1, 2003. Français. ⟨NNT : 2003NAN10015⟩. ⟨tel-01746785⟩

Share

Metrics

Record views

11