Skip to Main content Skip to Navigation
Theses

Réarrangements subtélomériques chez Streptomyces ambofaciens : duplications chromosomiques et cycle d'instabilité génomique

Abstract : In the Streptomyces ambofaciens bacteria, genetic instability is correlated with large chromosomal rearrangements (i.e. deletions) affecting the linear chromosome. The chromosomal structures of 4 different mutants were investigated. These 4 rearrangements consisted of deletions affecting a chromosomal arm and are all associated with the duplication of a part of the intact chromosomal arm (duplication from 480 kb to 6500 kb in size). Strains bearing a duplication of 6500 kb showed a phenotypic and chromosomal instability increase as compared to the other tested strains (duplication from 5 kb to 1440 kb, including wild type strain). These results permit us to describe an instability cycle analogous to the break-fusion-bridge cycle originally described in maize. We postulated that the duplication of the partition sites of the chromosome might be responsible for the instability of duplicated chromosomes, instability implied in the fast rate of evolution of the Streptomyces chromosomes.
Document type :
Theses
File URL :
http://docnum.univ-lorraine.fr/prive/SCD_T_2002_0283_WENNER.pdf
Complete list of metadatas

https://hal.univ-lorraine.fr/tel-01746809
Contributor : Thèses Ul <>
Submitted on : Thursday, March 29, 2018 - 10:45:15 AM
Last modification on : Monday, October 19, 2020 - 2:00:57 PM

Identifiers

  • HAL Id : tel-01746809, version 1

Citation

Thomas Wenner. Réarrangements subtélomériques chez Streptomyces ambofaciens : duplications chromosomiques et cycle d'instabilité génomique. Génétique. Université Henri Poincaré - Nancy 1, 2002. Français. ⟨NNT : 2002NAN10283⟩. ⟨tel-01746809⟩

Share

Metrics

Record views

54