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Implication des récepteurs à l'acide rétinoïque et aux rétinoïdes X dans la modulation de certaines composantes de la réaction immunitaire chez le rat

Abstract : Vitamin A deficiency is associated with increased susceptibility of the host to infection. Vitamin A supplementation, through its active metabolite, retinoic acid (RA) has «anti-infectious» effects by modulating the host inflammatory and immune responses through uncompletely characterized mechanisms. The biological effects of RA are mediated by two types of nuclear receptors, the RA receptor(RAR) and the retinoid X (RXR). The mechanisms and the receptors isoforms through which RA modulates the host inflammatory/immune response were studied in vivo in rats in a model of RA supplementation and challenge with lipopolysaccharide (LPS). Supplementation with RA for 5 days enhanced, in an organ-specifi manner, the LPS-triggered activation of the unducible NO synthase (NOS2), m sharp contrast wlth previous in vitro studies. The organ-specific interaction of RA with LPS did not depend on the level of expresion of the RARa protein. RA and LPS synergistically decreased the expression of RXRs PPAR. Nevertheless, the RA-LPS interaction was mimicked by a RAR[alpha] but not by a panRXRs agonist. The RAR[alpha] agonist also mimicked the effects' of RA and increased the number of T CD4 lymphocytes, the production of type II interferon and the expression of l'lRF1l. These results contribute to the characterization of the « anti-infectious » properties of vitamm A.
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Theses
File URL :
http://docnum.univ-lorraine.fr/prive/SCD_T_2001_0284_SEGUIN_DEVAUX.pdf
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https://hal.univ-lorraine.fr/tel-01746865
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Submitted on : Thursday, March 29, 2018 - 10:46:27 AM
Last modification on : Monday, December 14, 2020 - 2:50:56 PM

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  • HAL Id : tel-01746865, version 1

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Carole Seguin Devaux. Implication des récepteurs à l'acide rétinoïque et aux rétinoïdes X dans la modulation de certaines composantes de la réaction immunitaire chez le rat. Biologie animale. Université Henri Poincaré - Nancy 1, 2001. Français. ⟨NNT : 2001NAN11313⟩. ⟨tel-01746865⟩

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