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Contribution à l'étude de la leptine et de son transport plasmatique dans l'obésité humaine

Abstract : Leptin is an adipocyte-secreted hormone that exerts a major effect on satiety. In humans and in mice, leptin or leptin receptor deficiency induces severe obesity arising as early as in childhood. Nevertheless, in common obesity, leptin levels are elevated, suggesting that the hallmark of obesity is not leptin deficiency but hyperleptinemia. This phenomenon is called leptin resistance. The aim of this study was to investigate the relationship between fat mass, leptin and soluble leptin receptor (SLR) in an attempt to analyse the mechanism responsible for leptin resistance. Our data show that common obesity is characterised by hyperleptinemia expressed in absolute and relative terms and taking into account free and bound leptin. We have observed that SLR levels are strongly diminished in the case of common obesity. Plasma leptin levels and fat mass are correlated in a group of obese women. This correlation is only observed in women who are moderately obese. Indeed, this correlation is not found in obese women with severe obesity. Interestingly, there is an independent positive correlation between fat mass and leptin and a negative correlation between fat mass and SLR. However, we observed that in the case of people affected by severe obesity there is a negative correlation between leptin and SLR levels. What we suggest, then, is that in common moderate obesity, the SLR is a determinant or determined factor of fat mass independently of leptin. We further suggest that hyperleptinemia induces a lower expression of SLR in subjects with severe obesity but with a non-mutated leptin receptor.
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Theses
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http://docnum.univ-lorraine.fr/prive/SCD_T_2002_0052_OGIER.pdf
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Submitted on : Thursday, March 29, 2018 - 10:46:30 AM
Last modification on : Wednesday, October 14, 2020 - 3:53:29 AM

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Virginie Ogier. Contribution à l'étude de la leptine et de son transport plasmatique dans l'obésité humaine. Biochimie, Biologie Moléculaire. Université Henri Poincaré - Nancy 1, 2002. Français. ⟨NNT : 2002NAN10052⟩. ⟨tel-01746867⟩

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