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Apolipoprotéine E, estrogènes et stress oxydant

Abstract : An imbalance between oxidant and antioxydant defense systems plays a central role in the pathogenesis of a number of age-related human diseases, notably cardiovascular diseases. Hormonal or estrogen replacement therapies (HRT or ERT) in post-menopausal women are expected to play antioxydant functions. Estrogens have both direct pro-oxidant and anti-oxidant activities in vitro. This pro-oxidant activity is unlikely to occur in vivo, while the antioxidant activity is modest. We aimed at evaluating the impact of ERT or HRT on biological parameters related to oxidative stress. To do so, we measured the serum concentrations of an indicator of total antioxidant status (TAS) and related factors such as copper, zinc, iron and transferrin in a population of 229 randomly selected postmenopausal women with or without HRT or ERT, as well as in 100 premenopausal women. Usual biological parameters were also assessed. Menopause was characterized by higher serum concentrations of alkaline phosphatase, apolipoproteins AI and E, zinc and TAS. Among these parameters, ERT or HRT use influenced alkalie phosphatase and alipoprotein E, bringing them back to premenopausal levels. HRT also influenced the concentrations of TAS, which were higher in treated than in untreated postmenopausal women. Uric acid, total proteins and albumin were positively correlated to TAS independently on replacement therapies. In conclusion, at physiological concentration, ERT or HRT participate in the increase of the antioxidant capacity of serum in postmenopausal women.
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Submitted on : Thursday, March 29, 2018 - 10:47:58 AM
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Marjorie Starck. Apolipoprotéine E, estrogènes et stress oxydant. Médecine humaine et pathologie. Université Henri Poincaré - Nancy 1, 2000. Français. ⟨NNT : 2000NAN10326⟩. ⟨tel-01746930⟩



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