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Theses

Etudes expérimentale chez le lapin et clinique chez l'Homme des biomatériaux d'indentation

Abstract : Scleral buckling is commonly used in external treatrnent of retinal detachment. With the help of various biomaterials, it contributes to reattach the retina. Three different biomaterials have been studied both clinically and experimentally. The results of our studies showed that, after implantation, silicone explants became encapsulated and their inner fibrous capsular surface was smooth, regular, devoid of fragments, and without significant inflammatory reaction. Conversely, implanted hydrogel explants exhibited fragments under their capsular sheath, often associated with a giant cell foreign body granuloma and these changes were found both in rabbit eyes and in human eyes and capsule specimens. Additionally, implanted e-PTFE explants made of a porous material underwent encapsulation and colonisation of their inner channels by inflammatory cells, fibroblasts with collagen deposits, and new vessels, all located peripherally in the explants, which were surrounded by giant cells in response to their irregular outer surface. With our studies, we could demonstrate that the hydrogel was not a stable rnaterial after implantation and that e-PTFE could become incorporated in the tissues, characteristic interesting for its future stability, but possibly annoying in case of reoperations.
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http://docnum.univ-lorraine.fr/prive/SCD_T_2000_0328_HERMIES.pdf
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https://hal.univ-lorraine.fr/tel-01746932
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Submitted on : Thursday, March 29, 2018 - 10:48:00 AM
Last modification on : Friday, December 18, 2020 - 2:09:03 PM

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  • HAL Id : tel-01746932, version 1

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François d' Hermies. Etudes expérimentale chez le lapin et clinique chez l'Homme des biomatériaux d'indentation. Biologie animale. Université Henri Poincaré - Nancy 1, 2000. Français. ⟨NNT : 2000NAN10328⟩. ⟨tel-01746932⟩

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