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Rôles de l'Oxygène et du Monoxyde d'Azote dans les lésions oxydatives cellulaires au niveau du poumon en développement

Abstract : Broncho-Pulmonary Dysplasia (BDP) is a frequent respiratory sequel in premature infants. The acknowledgment that primitive vascular alteration may enhance BPD lead to explore the hypothesis of early micro vascular injury, in the developing lung. We found on cell culture models, that CYP450LA1 gene was highly inducible by hyperoxia in micro vascular pulmonary endothelial cells. Through this induction, the hyperoxic endothelial cell releases high amounts of toxic free radicals, with massive cellular death contiguously. This induction ofthe CYP450 gene is direct, specifie and transcriptiona!. Back te clinical research, we measured the oxidative stress of 240 premature infants, 23 to 31 weeks gestation, receiving high inspired oxygen concentration with or without the addition of inhaled nitric oxide (NO), in a prospective, controlled, randomized trial. lnhaled NO, given early at small dosage (< or = 5 ppm) in premature infants with hypoxemic respiratory failure, is able to reduce their oxidative stress and significantly reduces their oxygen requirements. Finally, further studies are needed to confirm the potential role of NO on pulmonary micro vascular remodeling and re-alveolarization in the injured human developing lung.
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Theses
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http://docnum.univ-lorraine.fr/prive/SCD_T_2004_0246_HAMON.pdf
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https://hal.univ-lorraine.fr/tel-01746943
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Submitted on : Thursday, March 29, 2018 - 10:48:11 AM
Last modification on : Tuesday, September 1, 2020 - 2:15:16 PM

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  • HAL Id : tel-01746943, version 1

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Isabelle Hamon. Rôles de l'Oxygène et du Monoxyde d'Azote dans les lésions oxydatives cellulaires au niveau du poumon en développement. Médecine humaine et pathologie. Université Henri Poincaré - Nancy 1, 2004. Français. ⟨NNT : 2004NAN10246⟩. ⟨tel-01746943⟩

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