Conséquences à long terme d'une carence maternelle en groupements méthyles chez le rat : effets conjugués de l'hyperhomocystéinémie et de l'hypoxie

Abstract : Maternal deficiency in methylgroups during pregnancy induces hyperhomocystemia in the child with known adverse effects. depending on its properties, transient hypoxia may exert beneficial effects by inducing tolerance. Our main goal was to investigate the combined effects of early hyperhomocystemia and brief neonatal hypoxia in a rat model designed to mimic clinical consequences of maternal deficiency in vitamins B12, B2, folate and choline. Whereas newborn rats display growth retardation with skeleton abnormalities, they develop moderate hyperhomocystemia, in line with disturbances in homocysteme liver metabolism and a concomitant steatosis. Maternal deficiency was also associated with an altered neurobehavioral development in the offspring, with reduced scores being recorded in various experimental tests. This may result from cerabral cell loss, as suggest by increased apoptis in brain areas that specificially accumulate homocysteine (hippocampus, cerebelum...). Brief neonatal hypoxia was able to improve the scores of deficient rats in a test of locomotor coordination probably by stimulating neurogenesis.
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http://docnum.univ-lorraine.fr/prive/SCD_T_2005_0216_BLAISE.pdf
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Submitted on : Thursday, March 29, 2018 - 10:48:46 AM
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Sébastien Blaise. Conséquences à long terme d'une carence maternelle en groupements méthyles chez le rat : effets conjugués de l'hyperhomocystéinémie et de l'hypoxie. Sciences agricoles. Université Henri Poincaré - Nancy 1, 2005. Français. ⟨NNT : 2005NAN11314⟩. ⟨tel-01746970⟩

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