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Theses

Intérêt des séquences pondérées T2 dans la caractérisation tissulaire du cartilage

Abstract : The comprehension of the pathologic processes affecting the cartilage is a challenging task since cartilage abnormalities are found in most of the rheumatic diseases while this tissue is by nature, not accessible to any technique of analysis performed on tissue samplings. MR imaging has been shawn to directly visualize the cartilage contrary to other imaging approaches but reports were as far conflicting regarding the real significance of what is depicted in MR. T1 and T2-weighted sequences similar to those used in the clinics were performed on bovine patellar specimens using a 1.5T clinical MR scanner. We showed Tl-weighted sequences were accurate to depict the limits of the cartilage and thus todetermine its thickness but these sequences could not permit to characterize the cartilage structure itself, depicted as homogeneous. Conversely, MR pattern of cartilage with T2-weighted sequences is heterogeneous and our data, supported by correlations with histology and biochemistry, show that this heterogeneity is not artefactual but reflects the variations in the cartilage structure. In complement to this imaging approach, we showed on rat patellar cartilage and using a 8.5T imager, that T2 mapping technique was effective to characterize the evolution of the cartilage matrix content and thikness with maturation process. Thus, MR T2 sequences with both imaging and mapping approaches make MR as being a very promising non invasive technique to assess the cartilage structure and its variations.
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Theses
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http://docnum.univ-lorraine.fr/prive/SCD_T_2001_0281_OLIVIER.pdf
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https://hal.univ-lorraine.fr/tel-01747021
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Submitted on : Thursday, March 29, 2018 - 10:49:38 AM
Last modification on : Friday, February 26, 2021 - 3:00:04 PM

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  • HAL Id : tel-01747021, version 1

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Pierre Olivier. Intérêt des séquences pondérées T2 dans la caractérisation tissulaire du cartilage. Médecine humaine et pathologie. Université Henri Poincaré - Nancy 1, 2001. Français. ⟨NNT : 2001NAN10281⟩. ⟨tel-01747021⟩

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