Skip to Main content Skip to Navigation
Theses

Actions et mécanismes d'actions cardiovasculaires des glucocorticoïdes dans un modèle expérimental de choc septique chez le rat

Abstract : Glucocorticoids can reverse hemodynamic disturbances and dependence on catecholamines in septic shock. The relevant beneficial mechanims of steroids in septic shock are unknown, although inducible nitric oxide synthase could account for them. The aim of this study was to compare the effects of dexamethasone, a glucocorticoid, and L-canavanine, a selective inhibitor of inducible nitric oxide synthase, in a rodent model of sepsis. Mean arterial pressure was restored by dexamethasone and L-canavanine administration at 24 hours, no longer at 30 hours. Dexamethasone but not L-canavanine improved aortic blood flow at 24 and 30 hours. Although both dexamethasone and L-canavanine administration significantly reduced nitrite/nitrate production, and improved survival, steroids did better for survival. In conclusion, dexamethasone and L-canavanine displayed similar vasopressor effects. In addition, steroids improved blood flow suggesting that steroid-induced hemodynamic improvement in sepsis is not solely due to inhibition of inducible nitric oxide synthase.
Document type :
Theses
File URL :
http://docnum.univ-lorraine.fr/prive/SCD_T_2002_0302_MANSART.pdf
Complete list of metadatas

https://hal.univ-lorraine.fr/tel-01747037
Contributor : Thèses Ul <>
Submitted on : Thursday, March 29, 2018 - 10:49:53 AM
Last modification on : Monday, October 5, 2020 - 3:20:55 PM

Identifiers

  • HAL Id : tel-01747037, version 1

Collections

Citation

Arnaud Mansart. Actions et mécanismes d'actions cardiovasculaires des glucocorticoïdes dans un modèle expérimental de choc septique chez le rat. Médecine humaine et pathologie. Université Henri Poincaré - Nancy 1, 2002. Français. ⟨NNT : 2002NAN10302⟩. ⟨tel-01747037⟩

Share

Metrics

Record views

12