Médicaments à effet rénal administrés chez la mère pendant la gestation : néphrotoxicité éventuelle chez le nouveau-né : modulations pharmacologiques du développement fonctionnel rénal foetal et néonatal chez le rat après exposition in-utero à la Gentamicine ou au Furosémide

Abstract : Aminoglycosides (gentamicin) antibiotics well-known for their nephrotoxicity; and furosemide, a widely used diuretic, has been reported to induce a delay in the differentiation of renal glomeruli. We were interested to investigate if the developing kidney could be functionally altered in-utero after administration of either these drugs to the pregnant mother. Drugs were given during two keyperiods of pregnancy: days 7-11 (period of organogenesis) and days 14-18 (beginning of glomeruli differentiation) at the dose of 75mg/Kg/day by i.p. route. The rat strain was WISTAR.Shortly after birth,variations were observed on diuresis, creatinine clearance, U/P creatinine ratio,fractional excretion of water fractional excretion of electrolytes. The gentamicin-induced nephrotoxicity was reversible, the glomerular function being corrected earlier than the tubular urinary concentrating defect. Furosemide seemed to lead to a delay of development of loop of Henle, suggesting a functional adaptation of other segments of tubule, already mature and functionning. Furthermore, our results provide evidences of functional developmental disturbances (altered growth and urinary concentrating defect) in young rats, lately after prenatal exposure to furosemide or gentamicin. In conclusion, drug administration to mother during pregnancy can lead to a detrmental effect upon the kidney of the newborn and of the young animal.
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Pierre Boudzoumou-Nganga. Médicaments à effet rénal administrés chez la mère pendant la gestation : néphrotoxicité éventuelle chez le nouveau-né : modulations pharmacologiques du développement fonctionnel rénal foetal et néonatal chez le rat après exposition in-utero à la Gentamicine ou au Furosémide. Médecine humaine et pathologie. Université Henri Poincaré - Nancy 1, 1989. Français. ⟨NNT : 1990NAN10550⟩. ⟨tel-01747178⟩

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