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Organisation moléculaire et étude des promoteurs de la gamma-glutamyltransférase humaine

Abstract : The catabolism of glutathione and glutathion conjugates is initiated by the cleavage of the y-glutamyl moiety by the only enzyme y-glutamyltransferase (GGT E C 3.2.2.2). This heterodimeric glycoprotein arise From the proteolytic cleavage of a precursor and it is localized on the outer face of the plasma membrane. Important variations in GGT activity are known to occur during development, carcinogenesis and cell differentiation. It is commonly admitted that GGT participates in the active transport of aminoacids, but also in other biochemical pathways such as detoxification or inflammatory responses by processing GSH-conjugated electrophiles and leukotrienes. GGT genomic organization is well established in rat and mouse. A unique gene encodes several mRNA species that differ in the il' 5' untranslated regions. These mRNAs are transcribed under the control of several tissue-specific promoters which have been described here.
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Submitted on : Thursday, March 29, 2018 - 10:57:57 AM
Last modification on : Monday, February 15, 2021 - 1:49:23 PM

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  • HAL Id : tel-01747361, version 1

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Hervé Leh. Organisation moléculaire et étude des promoteurs de la gamma-glutamyltransférase humaine. Biochimie, Biologie Moléculaire. Université Henri Poincaré - Nancy 1, 1997. Français. ⟨NNT : 1997NAN12159⟩. ⟨tel-01747361⟩

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