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Theses

Risque de thrombose veineuse associé aux anticorps antiphospholipides

Abstract : We have studied the risk of venous thromboembolism associated with antiphospholipid antibodies. Our first objective was to determine the risk for a first documented venous thrombosis associated with antiphospholipid antibodies. We have conducted a systematic review of the literature and a meta-analysis to estimate to estimate the risk of venous thrombosis associated with antiphospholipid antibodies. We have shown, both in lupus and non lupus patients, that the risk of venous thrombosis associated with lupus anticoagulant was higher than with anticardiolipin antibodies. Our second objective was to assess the risk of recurrence after a first event. Conducting a retrospective cohort study of non lupus patients, we have also shown that anti-[Beta]2-glycoprotein I antibodies were associated with a greater risk of recurrent venous thrombosis than antiphospholipid antibodies detected by conventional tests.
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http://docnum.univ-lorraine.fr/prive/SCD_T_1998_0346_WAHL.pdf
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https://hal.univ-lorraine.fr/tel-01747476
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Submitted on : Thursday, March 29, 2018 - 11:01:01 AM
Last modification on : Tuesday, February 9, 2021 - 2:54:43 PM

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  • HAL Id : tel-01747476, version 1

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Denis Wahl. Risque de thrombose veineuse associé aux anticorps antiphospholipides. Médecine humaine et pathologie. Université Henri Poincaré - Nancy 1, 1998. Français. ⟨NNT : 1998NAN11008⟩. ⟨tel-01747476⟩

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