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Imagerie de Diffusion par RMN : Optimisation des Paramètres et Applications Cliniques pour les Explorations Hépatiques

Abstract : Magnetic Resonance (MR) allows to obtain high quality anatomical and morphological images. Thanks to the recent developments on clinical systems, it is possible to add functional information that we associate with these morphological data. We were interested in Diffusion Weighted Imaging (DWI) by MR for hepatic explorations. This technique measures the microscopic movements of water allowing to obtain a functional parameters like the Apparent Diffusion Coefficient (ADC). However, this information is very sensitive to cardio-respiratory motions. We analysed the different MR parameters; the b value, the size and the position of the region of interest, different methods of fat suppression, and the benefit of a cardiac trigger and/or respiratory trigger. Potential of the DWI for clinical applications are the quantification of the fibrosis within the framework of the diffuse diseases and an optimization of the characterization of the hepatic focal lesions. We correlated DWI with histology, in order to understand the interpretation of the new information obtained. DWI has a large potential for the detection and characterization of the focal lesions. However, the management of motion is important to obtain correct ADC values. We fund many limits to use DWI for clinical routine.
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Submitted on : Thursday, March 29, 2018 - 11:28:18 AM
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Valérie Croisé-Laurent. Imagerie de Diffusion par RMN : Optimisation des Paramètres et Applications Cliniques pour les Explorations Hépatiques. Médecine humaine et pathologie. Université Henri Poincaré - Nancy 1, 2008. Français. ⟨NNT : 2008NAN10149⟩. ⟨tel-01748198⟩



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