Incidences comportementales et physiologiques d'une obstruction nasale bilatérale chez le rat en développement

Abstract : This work is part of a research program dealing with the consequences of bilateral nasal obstruction (NO) during the postnatal development of mammals. Its aim was to test whether NO could alter the exploratory behaviour and induce a stress response, which could perturb the development of the individual. Therefore, a NO was induced in 8-day old rats (D8) and its effects were investigated 24h after the treatment (D9), at the end of the obstruction period (D15) and six days after the reopening of the nostrils (D21). The results showed that NO deteriorated the exploratory behaviour. The orientating abilities, the novelty-seeking behaviour and the performances in a spatial learning task were indeed altered. Besides, a decreased food intake associated with a growth deceleration was observed in NO animals. These disturbances were abrogated, even reversed, with the reopening of the nostrils. The modifications of respiratory behaviour generated an adaptative response of oro-facial muscles which presented, at D21, a profile in myosin heavy chains adapted to chronic oral breathing. In addition, NO involved a hypercorticosteronemy and a hypothyroidism at D9, D15 and D21. These hormonal modifications were more pronounced in females. Lastly, NO was associated with an atrophy of the spleen and the thymus at D15. The thymic atrophy was maintained until D21 in females, which showed, at this age, a decrease of thymocyte proliferative response. In rats, nasal obstruction can thus be considered like a multifactorial stressfull situation. Its impacts are more pronounced in females and could persist at the adulthood.
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Mathieu Gelhaye. Incidences comportementales et physiologiques d'une obstruction nasale bilatérale chez le rat en développement. Médecine humaine et pathologie. Université Henri Poincaré - Nancy 1, 2007. Français. ⟨NNT : 2007NAN10078⟩. ⟨tel-01748259⟩

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