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Modification de la surface luminale artérielle par films de polyelectrolytes en vue d'obtenir un substitut vasculaire non thrombogénique

Abstract : The enhancement of cardiovascular pathology frequencies and unavailability of the adequate therapies will imply during the next decades an important requirement in vascular substitutes, especially for small calibre. The aim of this study is to elaborate a functional vascular substitute. We present here a new procedure to treat cryopreserved arteries based on their inner surface coating with poly(sodium-4-styrene sulfonate)/poly(allylamine hydrochloride) polyelectrolyte multilayer (PEM). We show that this treatment improves the mechanical properties of the cryopreserved vessel. In order to elaborate an antithrombogenic luminal surface two approaches have been considered. The first was to improve the endothelium formation when the terminal layer is a polycation. The second was to prevent cell adhesion on the negative luminal surface. In vitro results show that PEM allows the endothelial cell spreading and an enhancement of cell retention to shear stress. In vivo results show a good graft patency during three months of implantation after rabbit carotid replacement. All these promising results open the route towards the development of future new biocompatible tissue substitutes allowing long-term functionality after implantation.
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Halima-Assia Kerdjoudj. Modification de la surface luminale artérielle par films de polyelectrolytes en vue d'obtenir un substitut vasculaire non thrombogénique. Biotechnologies. Université Henri Poincaré - Nancy 1, 2007. Français. ⟨NNT : 2007NAN10146⟩. ⟨tel-01748402⟩

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