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Etude des adipokines en relation avec le syndrome métabolique et l'inflammation

Abstract : The metabolic syndrome (MS) raises the risk for developing diabetes and cardiovascular disease. The components of this state are obesity, hypertension, disturbed lipid profile, insulin resistance, inflammation and hepatic steatosis. The excessive accumulation of fat mass, particularly in the abdomen, leads to low-grade systemic inflammation. Indeed, the adipose tissue produces adipokines such as leptin, visfatin, IL-6 and TNF-a that are implicated in the inflammatory processes. Our goal was to study: 1) the associations between 5 year-changes of the body mass index (BMI) and circulating leptin concentrations with the factors of the MS and 2) the expression of some adipokines in the lymphocytes. The STANISLAS cohort has enabled us to fulfil our research work (collection of a great number of data concerning MS factors, bio-banks: lymphocytes, serum, plasma, DNA). The longitudinal study on BMI changes and the factors associated with MS has shown that some of these factors evolve together (clusters) and that these groups of factors are associated with BMI changes in a sex dependent manner. We described also, associations of circulating leptin with MS factors, dependent to sex and independently of fat mass. Finally, we were able to detect and quantify mRNA of adipokines in lymphocytes. The quantification of the mRNA has shown associations of visfatin with BMI and gene expression of TNF-a and of leptin with blood pressure. The results obtained by this research work underline the mediating role of leptin and the impact of sex on the actions of this hormone and offers new perspectives for studying adipokines in the context of inflammation, by proposing a new model: PBMCs.
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Anastasia Samara. Etude des adipokines en relation avec le syndrome métabolique et l'inflammation. Médecine humaine et pathologie. Université Henri Poincaré - Nancy 1, 2008. Français. ⟨NNT : 2008NAN10105⟩. ⟨tel-01748521⟩

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