Réactivité de silices fonctionnalisées par des groupements dithiocarbamates vis-à-vis de Co(II) et Ni(II) : vers une nouvelle méthode de diagnostic de l'exposition aux métaux lourds lors du recueil des urines

Abstract : The main object of the thesis concerns the development of a trapping method for quantitative analysis of carcinogenic - or likely to be - metal ions in urine, allowing to avoid sample transport in a liquid form. Among the metal ions a trace levels, we have been particularly interested in cobalt and nickel species. The approach presented here is based on solid/liquid extraction of metal ions by complexation on mesoporous organic-inorganic hybrid materials with large specific surface areas. The selected adsorbents are silica gels functionalised with dithiocarbamate groups. After their preparation by post-synthesis grafting using new siloxydithiocarbamate precursors, the functionalized silica gels have been characterized by various physico-chemical techniques and their behaviour in solution has been investigated. It shows that interactions between dithiocarbamate moieties and the silica surface can lead to a loss of grafted groups in the external solution, especially for extended periods in aqueous medium. However, these hybrids have been successfully used for quantitative sequestration of CoII and NiII from dilute solutions (1 to 500 µg L-1), within the pH range likely to be encountered in urinary environment. This study has also involved the development of an analytical method for the simultaneous and quantitative determination of these elements in solution. This was based on high performance liquid chromatography for which the best results were obtained using the switching column technique. Adsorption operations have proven to be very fast, which has allowed operating effectively in the implementation of cartridges through which the samples have been percolated. Efforts have also been made to define the optimal conditions for desorption, which was then applied to the quantitative analysis of analytes previously accumulated in the cartridge.
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Lydie Tzanis. Réactivité de silices fonctionnalisées par des groupements dithiocarbamates vis-à-vis de Co(II) et Ni(II) : vers une nouvelle méthode de diagnostic de l'exposition aux métaux lourds lors du recueil des urines. Autre. Université Henri Poincaré - Nancy 1, 2008. Français. ⟨NNT : 2008NAN10098⟩. ⟨tel-01748541⟩

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