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Nouveaux catalyseurs au nickel pour la création de liaisons carbone-azote et applications à la synthèse sélective d'arylpipérazines

Abstract : The work described in this thesis reports the elaboration of a new nickel(0) catalyst allowing arylamination reactions starting from aryl chlorides and amines. The reagent (noted Ni/bpy) constituted of Ni(0) clusters liganded by 2,2'-bipyridine allows an efficient synthesis of a broad range of arylamines either by inter- or intramolecular process. We also showed that, contrary to palladium reagents, the Ni/bpy catalyst allowed the selective and high yielding monoarylation of diamines using stoichiometric amounts of starting materials. Efficient syntheses of N-arylpiperazines have thus been developed starting from readily available aryl chlorides. Finally, diarylation processes allowing the synthesis of symmetrical or unsymmetrical N,N'-diarylpiperazines are also described.
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Eric Brenner. Nouveaux catalyseurs au nickel pour la création de liaisons carbone-azote et applications à la synthèse sélective d'arylpipérazines. Autre. Université Henri Poincaré - Nancy 1, 2001. Français. ⟨NNT : 2001NAN10198⟩. ⟨tel-01748570⟩

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