Influence de la sensibilité à l'insuline et de l'obésité sur le métabolisme post-prandial des lipoprotéines riches en triglycérides

Abstract : The dietary intake of a normal human being having at least three fat-containing meals per day, leads to repeated changes in the lipid balance which are only partially reflected in the fasting state. Advances in our knowledge of the biochemistry and molecular, biology of lipids have shown that the triglyceride-rich , lipoproteins are atherogen, ic, especially during the postprandial period. Postprandiallipid metabolism has been clearly demonstrated ito be altered in obesity, type 2 diabetes, and also in patients with hypertension or cardiovascular disease. Triglyceride-rich lipoproteins derived from live are believed to be responsible for these lipid alterations, when the insu lin sensitivity is reduced. This decrease of insulinsensitivity leads to alterations of lipid metabolisn involving enzymes, liver and adipocytes, resulting in metabolic competition between the triglyceride-rich lipoproteins from the gut and those from the liver during the postprandial state. But the analysis of postprandial metabolism is hindered by methodologicai difficulties, and there is now a need to standardize lipid analyses and hence simplify their performance.
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Bruno Guerci. Influence de la sensibilité à l'insuline et de l'obésité sur le métabolisme post-prandial des lipoprotéines riches en triglycérides. Médecine humaine et pathologie. Université Henri Poincaré - Nancy 1, 2001. Français. ⟨NNT : 2001NAN11306⟩. ⟨tel-01748670⟩

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