Réalisation de couplages pallado-catalysés en série thiophénique : synthèse de composés biologiquement actifs

Abstract : N-Arylation of primary and secondary amines by Buchwald-Hartwig C-N cross-coupling reactions is a very convenient pathway for the synthesis of arylamines. Up to now, only few examples of arylamines synthesis were described in the thiophene series, although arylaminothiophenes generally show very interesting biological and electronic properties. Thus, we investigated the reactivity of 2- and 3- bromothiophene derivatives in palladium-catalyzed cross-coupling. Then we also studied the reactivity of aminothiophenes in those same cross-coupling reactions. Using this way, the expected diarylamines were successfully synthesized. An easy access to thienopyrimidinone derivatives was also described via a one-pot C-N coupling and intramolecular cyclization
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Agathe Begouin. Réalisation de couplages pallado-catalysés en série thiophénique : synthèse de composés biologiquement actifs. Autre. Université Paul Verlaine - Metz, 2007. Français. ⟨NNT : 2007METZ020S⟩. ⟨tel-01748993⟩

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