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Caractérisation des propriétés pro- et anti-coagulantes associées aux cellules musculaires lisses vasculaires

Abstract : The main objective of this study was to compare the implication (i) of vascular cells, smooth muscle cells (SMC) and endothelial cells (EC), or circulating cells, platelets, and (ii) microparticles (MP) derived from these different cells in the generation of thrombin but also in its inhibition by the activated protein C (APC) and the tissue factor pathway inhibitor (TFPI), and to identify the mechanisms and determinants responsibles for observed differences between these different cell supports for coagulation. We have demonstrated that [alpha]v[gamma]3 integrin, the prothrombin receptor on the vascular surfaces, was involved in the generation of thrombin on the surface of these cells subjected or not subjected to cyclic mechanical deformations. At baseline, SMC and EC, have equivalent thrombin generating capacities, but less than that of platelets. We have shown a synergistic role of TFPI with APC in the inhibition of thrombin generation at the surface of these cells, more important with SMC than with EC. Taken together, our results suggest that SMC may exert procoagulant effects comparable to EC but with different regulations in response to pro-and anticoagulant factors, and that MP derived from vascular cells have a very higher thrombogenic activity compared to their parent cells
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Submitted on : Thursday, March 29, 2018 - 12:07:52 PM
Last modification on : Friday, October 23, 2020 - 4:42:19 PM
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  • HAL Id : tel-01749151, version 1



Rose Said. Caractérisation des propriétés pro- et anti-coagulantes associées aux cellules musculaires lisses vasculaires. Médecine humaine et pathologie. Université de Lorraine, 2012. Français. ⟨NNT : 2012LORR0004⟩. ⟨tel-01749151⟩



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