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Effet du benzo[a]pyrène sur la lipolyse in vitro et in vivo

Abstract : The administration of a single dose of B[a]P (0.5 mg/kg in IP) in male C57BL6/J mice, induces in less than 30 minutes a significant eduction of the lipolysis induced by epinephrine. This inhibition is at a maximum 24 h later. Lipolytic capacity returns to basal levels 72 h after injection. An injection (IP) of B[a]P (0.5 mg/kg/48h) for 14 d, induces a significant body weight gain (+43 %, p<0.01) in mice without detectable changes in food consumption. Moreover, chronic treatment with B[a]P induce significant alterations of gene expression in adipose tissue, whereas no modification is observed at the level of muscle. Our observations indicate that administration of B[a]P induces profound alterations in adipocyte metabolism. The adipocyte exposed to B[a]P exhibited a greatly diminished capacity to mobilize lipids, particularly if the receptor involved contained multiple seven transmembrane spanning domains. Furthermore, human cells were more sensitive to lower concentrations of B[a]P than murine cells.
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Philippe Irigaray. Effet du benzo[a]pyrène sur la lipolyse in vitro et in vivo. Sciences agricoles. Institut National Polytechnique de Lorraine, 2005. Français. ⟨NNT : 2005INPL012N⟩. ⟨tel-01749984⟩



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