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Optimisation des procédés de chromatographie préparative, application au procédé multicolonne continu Varicol

Abstract : A new continuous chromatographic process is presented. The basic principle of the new Varicol process is based on a non-synchronous shift of the inlet/outlet valves in a multicolumn system, in contrast to the known Simulated Moving Bed (SMB) process which employs a synchronous shift of inlet/outlet lines. The optimized operating conditions of a chromatographic process are difficult to estimate, since a large number of parameters are involved. A numerical optimization method is proposed to compare the performances of the classical chromatographic processes batch and SMB with the new Varicol process. A similar approach is used to optimize the operating conditions for these three processes. In a first part, a numerical example is considered. The influence of relevant parameters are presented for both batch and SMB processes : influence of the column length, influence of the packing particle size and influence of the recovery for the target compound. The selected objective function has a significant influence on the optimized process design. A detailed optimization is then performed to optimize the design of the new Varicol process in order to optimize the column distribution in the four zones of the process. Performances of both SMB and Varicol are compared for a 6-columns configuration. This numerical study shows the high flexibility of the Varicol process, which leads to a cheaper separation cost compared to the SMB process. In a second part, the separation of a racemic mixture of 1, 2, 3, 4-tetrahydro-1-naphtol is studied on a 5-columns continuous system. Both SMB and Varicol processes are compared. The obtained productivity is significantly higher with the Varicol process compared to the SMB process. The eluent consumption is also reduced. This experimental result confirms the conclusions of the numerical study : due to its high flexibility, the separation cost can be reduced, using the Varicol process.
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Submitted on : Thursday, March 29, 2018 - 12:43:00 PM
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  • HAL Id : tel-01750325, version 1



Olivier Ludemann-Hombourger. Optimisation des procédés de chromatographie préparative, application au procédé multicolonne continu Varicol. Alimentation et Nutrition. Institut National Polytechnique de Lorraine, 2001. Français. ⟨NNT : 2001INPL019N⟩. ⟨tel-01750325⟩



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