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Évaluation des risques sanitaires de la consommation d'eaux potentiellement chargées en résidus de médicaments

Abstract : The drug pollution is effective on environmental water compartments. Sewage treatment plants and water purification fail to remove all the molecules present in wastewater and their removal rate varies according to therapeutic classes. Therefore, pharmaceuticals residues are found in human consumption water. The aim of our study is to build a risk assessment to the health of the population who consume water which contain pharmaceuticals residues. As a first time, we identified the nature of the pharmaceutical wastewater contamination and human consumption water. The large number of medicinal products makes it impossible risk assessment for each molecule, we built a hierarchical method for quickly identification of active substance having a higher risk to make a complete sanitary risk assessment for these pharmaceuticals. This part of our work, allowed us to, in first step, identify the criteria to be taken into account for optimizing hierarchy. Then, we could select 12 molecules for which sanitary risk assessment could be implemented. We decided to focus on the quantitative risk assessment of the consumption of polluted water with traces of three cytostatic molecules identified as priorities with our ranking methodology: ifosfamide, cyclophosphamide and 5- FU and a mixture of these three drugs with same concentrations. Toxicity test (Trypan blue, comets assay, micronuclei test) helped us to analyze the dose-response relationship for these molecules. Thus, we could identify the hazardous potential of these substances, assess the dose-response relationship, and analyze occupational and environmental exposure of population to finally calculate the risk. Our sanitary quantitative risk assessment conclusions must be considered with caution given the nature of preliminary data
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Submitted on : Thursday, March 29, 2018 - 12:51:23 PM
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Tiphanie Deblonde. Évaluation des risques sanitaires de la consommation d'eaux potentiellement chargées en résidus de médicaments. Médecine humaine et pathologie. Université de Lorraine, 2013. Français. ⟨NNT : 2013LORR0295⟩. ⟨tel-01750648⟩

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